About Guthrie CenterGuthrie Center is a city in Guthrie County, Iowa, along the South Raccoon River. The population was 1,569 at the 2010 census. It is the county seat of Guthrie County.ResourcesAbout Guthrie CenterMain Street Guthrie CenterGuthrie Center SchoolsWeather in Guthrie CenterGuthrie Center RestaurantsGuthrie County HospitalGuthrie’s River Ruckus